The purpose of this study was to investigate the emotion regulation strategies that are used to control the negative emotions experienced by music therapists in clinical settings and the effects of self-compassion on the burnout of therapists. For this purpose, variables were measured using the emotional regulation strategies scale, psychological exhaustion scale, and self-compassion scale for 166 music therapists currently active in clinical practice, and SPSS 25.0 was used for statistical processing. The result is as follows. First, burnout showed negative correlations with both emotion regulation strategies and self-compassion, and emotional regulation strategies showed a significant positive correlation with self-compassion. Second, as a result of verifying the effect of self-compassion on the relationship between emotion regulation strategies and burnout, self-compassion has a partial mediating effect between emotion regulation strategies and burnout. Third, as a result of confirming the relationship between the sub-factors of emotion regulation strategies, burnout, and self-compassion, it was found that cognitive strategy had a significant effect on burnout among the sub-factors of emotion regulation strategies. And all factors except the self-kindness factor among the sub-factors of self-compassion were found to play a mediating role either fully or partially in the relationship between the cognitive strategies and the sub-factors of burnout. In conclusion, self-compassion can prevent or control the burnout of a music therapist by adding it to the emotion regulation strategies and the negative impact on the therapist's individual mental health can be reduced.