The purpose of this study is to determine the overall trends and effect size of domestic music therapy studies for schizophrenia patients from 1999 to 2020, and 62 master/doctoral theses and journal articles were selected for analysis. For this contents were analysed by dividing the research year, research method, research environment, research purpose, musical interventions and intervention characteristics, and Meta-analysis were conducted by selecting 32 experimental-control group design studies. As a result of the trend analysis, research on music therapy for patients with schizophrenia was constantly published. Research methods accounted for a higher proportion of experimental research than technical research, and the research environment did not differ much between hospitalization and local community. The research purpose was high proportion of the two areas in the psychological/motional and social areas, and the musical intervention made up the greatest proportion in mix intervention and singing&instrument. As for the characteristics of intervention, many studies consisted of less than 10 people, 11 to 15 sessions, twice a week, and more than 60 minutes. Meta-analysis yielded 120 effect sizes from 32 papers, and the overall average effect size was 1.26, which is a large effect size. The research environment showed great effect sizes in both hospitalization and the local community. The purpose of the study was effective in two areas: social and psychological/emotional. Musical intervention showed a large effect size in playing musical instruments, singing/playing musical instruments and mixed intervention. In the characteristics of intervention, it was found to be effective when there are more than 21 people, more than 21 sessions, three times a week, and more than 60 minutes.